Our lab studies the molecular mechanisms that control how progenitors that exist during development differentiate into the broad range of cell types that underpin adult organ function. We integrate single-cell omic approaches with new microscopy and computational tools to understand how genetic changes cause abnormal differentiation in the kidney and model these genetic changes in the renal stem-cell derived organoid with the aim of identifying new treatments for kidney disease.
- Whole kidneys grown in culture show how nephrons form
- Deep imaging through the nephron forming niche
- Subcellular resolution to progenitor biology
- Averaged nephron models