Lab Overview

Our lab studies the molecular mechanisms that control how progenitors that exist during development differentiate into the broad range of cell types that underpin adult organ function. We integrate single-cell omic approaches with new microscopy and computational tools to understand how genetic changes cause abnormal differentiation in the kidney and model these genetic changes in the renal stem-cell derived organoid with the aim of identifying new treatments for kidney disease.

  • Whole kidneys grown in culture show how nephrons form
  • Deep imaging through the nephron forming niche
  • Subcellular resolution to progenitor biology
  • Averaged nephron models