Our lab studies the molecular mechanisms that control how progenitors that exist during development differentiate into the broad range of cell types that underpin adult organ function. We integrate single-cell omic approaches with new microscopy and computational tools to understand how genetic changes cause abnormal differentiation in the kidney and model these genetic changes in the renal stem-cell derived organoid with the aim of identifying new treatments for kidney disease.
Artificial Kidney Project
Whole kidneys grown in culture show how nephrons form
Subcellular resolution to progenitor biology
Averaged nephron models
Developing mouse embryonic kidneys (2014 Nikon Small World in Motion Competition: Honorable Mention)
Time-lapse: Embryonic mouse kidney development (2013 Olympus BioScapes International Digital Imaging Competition: Honorable Mention)
Complexity of ureteric bud branching and nephron formation (2012 Nikon Small World in Motion: 3rd Place)